Green Electrospun Silk Fibroin Nanofibers Loaded with Cationic Ethosomes for Transdermal Drug Delivery

作     者：HONG Huoyan ZHANG Dongdong UN Si HAN Feng WANG Kaili JIANG Di WU Jinglei MO Xiumei WANG Hongsheng HONG Huoyan;ZHANG Dongdong;LIN Si;HAN Feng;WANG Kaili;JIANG Di;WU Jinglei;MO Xiumei;WANG Hongsheng

作者机构：Key Laboratory of Science&Technology of Eco-TextileMinistry of EducationShanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620P.R.China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2021年第37卷第3期

页      面：488-495页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0703[理学-化学] 

基　　金：This work was supported by the Project of the Science&Technology Commission of Shanghai Municipality China(Nos.18490740400 20DZ2254900). 

主　　题：Transdermal drug delivery Silk fibroin Ethosome Green electrospinning 

摘      要：Transdermal drug delivery system(TDDS)facilitates the controlled release of active ingredients penetrating through the skin,avoiding the liver first pass effect.Electrospinning is a simple process to fabricate ultrafine fibers with a higher specific surface area,making them excellent candidates for drug delivery.In current work,a novel silk fibroin(SF)nanofiber loaded with cationic ethosomes(CEs)was prepared via green electrospinning.The data of Fourier transform infrared spectroscopy(FTIR)and laser scanning confocal microscopy(LSCM)confirmed the existence of CEs in the SF nanofibers.The morphology of the nanofibers was not significantly affected by the incorporation of CEs as shown by scanning electron microscopy(SEM)images.The CEs-loaded SF nanofibrous patch(CEs-SFnP)showed good cytocompatibility as proved by both cell counting Kit-8(CCK-8)assay and SEM.Using doxorubicin hydrochloride(Dox)as a model drug,the transdermal performance of CEs-SFnP was evaluated through Franz diffusion cell against mouse skin.The results indicated that CEs-SFnP can effectively deliver drug into the skin,with a much higher permeation rate than the normal nanofibers without CEs.The as-spun CEs-SFnP in this study could find promising applications in TDDS.