Parabiosis modeling:protocol,application and perspectives

作     者：Cui Yang Zhi-Lan Liu Jun Wang Xian-Le Bu Yan-Jiang Wang Yang Xiang Cui Yang;Zhi-Lan Liu;Jun Wang;Xian-Le Bu;Yan-Jiang Wang;Yang Xiang

作者机构：Institute of NeurologySichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Chinese Academy of Sciences Sichuan Translational Medicine Research HospitalChengduSichuan 610072China Department of NeurologyGeneral Hospital of Western Theater CommandChengduSichuan 610083China Department of Neurology and Center for Clinical NeuroscienceDaping HospitalThird Military Medical UniversityChongqing 400012China Department of NeurologySichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China 

出 版 物：《Zoological Research》 (动物学研究(英文))

年 卷 期：2021年第42卷第3期

页      面：253-261页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 0905[农学-畜牧学] 0906[农学-兽医学] 0833[工学-城乡规划学] 10[医学] 0713[理学-生态学] 0834[工学-风景园林学（可授工学、农学学位）] 

基　　金：This study was supported by the National Natural Science Foundation of China(81601112,81801090) Top Project of Youth Incubation Program of Military Medical Science and Technology(19QNP065) Sichuan Department of Science and Technology Fund(2018SZ0141,2019YSF0213) China’s Post-doctoral Science Fund(2017M623357),and Sichuan Medical Association Fund(Q17008)。 

主　　题：Parabiosis Application Protocols Surgical technique Perioperative management 

摘      要：Parabiosis is a surgical method of animal modeling with a long history.It has been widely used in medical research,particularly in the fields of aging,stem cells,neuroscience,and immunity in the past two decades.The protocols for parabiosis have been improved many times and are now widely accepted.However,researchers need to consider many details,from surgical operation to perioperative management,to reduce mortality and maintain the parabiosis union.Although parabiosis has certain inevitable limitations,it still has broad application prospects as an irreplaceable animal model in the medical research field.