Large-duct pattern invasive adenocarcinoma of the pancreas–a variant mimicking pancreatic cystic neoplasms: A minireview

作     者：Hiroki Sato Andrew Scott Liss Yusuke Mizukami 

作者机构：Division of Gastroenterology and Hematology/OncologyDepartment of MedicineAsahikawa Medical UniversityAsahikawa 0788510HokkaidoJapan Department of SurgeryMassachusetts General Hospital and Harvard Medical SchoolMassachusetts General HospitalBostonMA 02114United States Institute of Biomedical ResearchSapporo Higashi Tokushukai HospitalSapporo 0650033HokkaidoJapan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2021年第27卷第23期

页      面：3262-3278页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Japan Society for the Promotion of Science(JSPS)KAKENHI No.19K17480(to Sato H) and No.20H03655(Mizukami Y) 

主　　题：Large-duct pattern invasive carcinoma of the pancreas Pancreatic ductal adenocarcinoma Pancreatic cystic disease Clinicopathological features of pancreatic cancer Pancreatic cancer subtype 

摘      要：Pancreatic cancer currently has no subtypes that inform clinical decisions;hence,there exists an opportunity to rearrange the morphological and molecular taxonomy that guides a better understanding of tumor ***,accumulating studies to date have revealed the large-duct type variant,a unique subtype of pancreatic ductal adenocarcinoma(PDA)with cystic *** subtype often radiographically mimics intraductal papillary mucinous neoplasms(IPMNs)and involves multiple small cysts occasionally associated with solid ***“bunch-of-grapessign,an imaging characteristic of IPMNs,is absent in large-duct ***-duct PDA defines the mucin profile,and genetic alterations are useful in distinguishing large-duct PDA from ***,neoplastic ducts measure over 0.5 mm,forming large ductal *** to classic PDAs,this subtype is frequently accompanied by perineural invasion and abundant desmoplastic reactions,and KRAS mutations in codon 12 are nearly *** such morphological similarities with IPMNs,the prognosis of large-duct PDA is equivalent to that of classic *** diagnosis is therefore essential.