Evaluation of a five-gene signature associated with stromal infiltration for diffuse large B-cell lymphoma
作者机构：Department of HematologyChongqing University Cancer HospitalChongqing 400030China
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2021年第9卷第18期
页 面：4585-4598页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by the Natural Science Foundation of Chongqing No.cstc2019jcyj-msxmX0793
主 题：Diffuse large B-cell lymphoma Co-expression Overexpression Stromal score Cancer-associated fibroblasts Therapeutic target
摘 要：BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is a common non-Hodgkin *** development of immunotherapy greatly improves the patient prognosis but there are some ***,screening for better biomarkers for prognostic evaluation could contribute to the treatment of DLBCL *** To screen the novel mediators involved in the development of *** The GSE60 dataset was applied to identify the differentially expressed genes(DEGs)in DLBCL,and the principal components analysis plot was used to determine the quality of the included *** protein-protein interactions were analyzed by the STRING *** key hub genes were entered into to the GEPIA database to determine their expressions in ***,these hub gene alterations were analyzed in *** UALCAN portal was employed to analyze the expression of the hub genes in different stages of *** Estimation of Stromal and Immune cells in Malignant Tumor tissues using Expression data Score was conducted to evaluate the correlation between the gene expression and tumor *** gene-gene correlation analysis was conducted in the *** stromal score analysis was conducted in TIMER to confirm the correlation between the gene expression and infiltrated stromal *** correlation between the indicated genes and infiltration level of cancerassociated fibroblasts(CAFs)was also completed in TIMER with two methods,MCP-Counter and Tumor immune dysfunction and *** correlation between fibronectin(FN1)protein level and secreted protein acidic and cysteinerich(SPARC)messenger ribonucleic acid expression was confirmed in the *** The top 20 DEGs in DLBCL were identified,and the principal components analysis plot confirmed the quality of the significant *** pairwise correlation coefficient analysis among all samples showed that these DEGs have a certain co-expression *** DEGs were subjected to STRING to identify the hub genes,alpha-2-macrogl
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