Anderson-Fabry disease presenting with atrial fibrillation as earlier sign in a young patient:A case report
作者机构：Department of Internal MedicineGyeongsang National University HospitalJinju 52727South Korea Department of Internal MedicineGyeongsang National University School of Medicine and Gyeongsang National University HospitalJinju 52727South Korea
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2021年第9卷第18期
页 面：4823-4828页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Fabry disease Atrial fibrillation Electrocardiography Cardioversion Glycosphingolipids Case report
摘 要：BACKGROUND Anderson-Fabry disease(AFD)is an X-linked lysosomal storage disorder that results from a deficiency ofα-galactosidase A enzyme activity in which glycosphingolipids gradually accumulate in multi-organ *** manifestations are the leading cause of mortality in patients with *** them,arrhythmias comprise a large portion of the heart disease cases in AFD,most of which are characterized by conduction ***,atrial fibrillation as a presenting sign at the young age group diagnosed with AFD is *** SUMMARY We report a case of a 26-year-old man who was admitted with chest *** ventricular hypertrophy was fulfilled in the criteria by the Sokolow-Lyon index and atrial fibrillation on the 12 Leads-electrocardiography(ECG)that was documented in the emergency *** spontaneously restored to normal sinus rhythm,relationships between P and R waves,including a shorter PR interval on the ECG,were *** echocardiographic findings showed thickened interventricular septal and left posterior ventricular *** on the clues mentioned earlier,we realized the possibility of ***,we noticed the associated symptoms and signs,including bilateral mild hearing loss,neuropathic pain,anhidrosis,and angiokeratoma on the trunk and *** was finally diagnosed with classical AFD,which was confirmed by the gene mutation and abnormal enzyme activity ofα-galactosidase *** This case is a rare case of AFD as a presentation with atrial fibrillation at a young *** the relationship between P and Q waves on the ECG through sinus rhythm conversion may help in differential diagnosis of the cause of atrial fibrillation and hypertrophic myocardium.
维普期刊数据库