Clinical characteristics of COVID-19 in family clusters: a systematic review
作者机构：Department of PediatricsShengjing Hospital of China Medical UniversityNo.36SanHao StreetShenyang110004China
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2021年第17卷第4期
页 面：355-363页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
基 金：This research was funded by the National Natural Science Foundation of China(No.81771621) the Natural Science Foundation of Liaoning Province(No.2019JH8/10300023)
主 题：Children Coronavirus disease 2019 Family clusters Severe acute respiratory syndrome coronavirus 2
摘 要：Background Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread around the world and reports of children during early epidemic period showed features of family *** aim of this study is to assess clinical profiles of COVID-19 in family clusters with *** We performed a systematic literature review of English database(PubMed,Web of Science)and Chinese database(“***,“***and“***)to identify papers on family clusters of COVID-19 with children and their family *** Eighteen studies involving 34 children and 98 adults from 28 families were ***,cough and ground-grass opacity change of chest computed tomography(CT)were the dominant features,whereas proportion of asymptomatic infections for children was higher than adults with statistical significance(32.4%and 13.3%,respectively,P0.05).Median time of longer incubation period(10 days)and shorter duration of pharyngeal swab nucleic acid test positive period(11 days)were seen in children than adults(7 and 17 days,respectively)with statistical significance(P0.05).There were statistically significant differences in lymphopenia,increased C-reactive protein and abnormal chest CT between children and adult patients(P0.05).Twenty-seven families reported adults as first case of COVID-19 in family *** The same virus strain can cause milder disease in children compared with their *** of COVID-19 were infected by adults in family during the early epidemic *** patients can transmit the virus.
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