Visualization of endoplasmic reticulum viscosity in the liver of mice with nonalcoholic fatty liver disease by a near-infrared fluorescence probe

作     者：Yongqing Zhou Zhenzhen Liu Guangming Qiao Bo Tang Ping Li Yongqing Zhou;Zhenzhen Liu;Guangming Qiao;Bo Tang;Ping Li

作者机构：College of ChemistryChemical Engineering and Materials ScienceKey Laboratory of Molecular and Nano ProbesMinistry of EducacionInstitutes of Biomedical SciencesShandong Normal UniversityJinan 250014China Environment Pollution Control CenterZibo 255000China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第11期

页      面：3641-3645页

核心收录：

学科分类：081704[工学-应用化学] 1002[医学-临床医学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0703[理学-化学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.21927811,91753111,22074083,21907061) the Key Research and Development Program of Shandong Province(No.2018YFJH0502) the National Major Scientific and Technological Special Project for"Significant New Drugs Development"(No.2017ZX09301030004) 

主　　题：Nonalcoholic fatty liver disease Endoplasmic reticulum stress Viscosity Fluorescence imaging probe 

摘      要：Nonalcoholic fatty liver disease(NAFLD)can cause serious liver *** diagnosis and effective treatment of NAFLD can greatly improve treatment *** initiation and development of NAFLD has been closely linked to endoplasmic reticulum(ER)stress,which might cause ER viscosity ***,if the internal relationship between ER viscosity and NAFLD is clarified,an effective approach for early diagnosis may ***,we fabricated a novel near-infrared(NIR)fluorescence imaging probe,Er-V,for monitoring ER viscosity through a molecular rotor ***-V exhibited a strong NIR fluorescence signal(at 626 nm)when the environmental viscosity hindered the rotation of the malononitrile *** Er-V,we successfully observed a significant enhancement in viscosity in the liver of mice with ***,this imaging method based on Er-V is expected to provide a new approach for early detection and diagnosis of NAFLD.