Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson’s disease

作     者：Kai Zhang Shiou Zhu Jiamei Li Tingting Jiang Lu Feng Junping Pei Guan Wang Liang Ouyang Bo Liu Kai Zhang;Shiou Zhu;Jiamei Li;Tingting Jiang;Lu Feng;Junping Pei;Guan Wang;Liang Ouyang;Bo Liu

作者机构：State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalCollaborative Innovation Center of BiotherapySichuan UniversityChengdu 610041China Innovation Center of Nursing ResearchNursing Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengdu 610041China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2021年第11卷第10期

页      面：3015-3034页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：financially supported by National Science and Technology Major Project of the Ministry of Science and Technology of the People’s Republic of China(No.2018ZX09735005) National Natural Science Foundation of China(Grant Nos.81803755,81673455 and 81922064) Sichuan University Postdoctoral Research and Development Foundation(Grant No.2020SCU12062,China) Sichuan Science and Technology Program(Grant No.2019JDRC0091,China) 

主　　题：Parkinson’s disease(PD) Autophagy Target Small-molecule compound PD therapy 

摘      要：Parkinson’s disease(PD),known as one of the most universal neurodegenerative diseases,is a serious threat to the health of the *** current treatment has been demonstrated to relieve symptoms,and the discovery of new small-molecule compounds has been regarded as a promising *** note,the homeostasis of the autolysosome pathway(ALP)is closely associated with PD,and impaired autophagy may cause the death of neurons and thereby accelerating the progress of ***,pharmacological targeting autophagy with small-molecule compounds has been drawn a rising attention so *** this review,we focus on summarizing several autophagy-associated targets,such as AMPK,m TORC1,ULK1,IMPase,LRRK2,beclin-1,TFEB,GCase,ERRα,C-Abelson,and as well as their relevant small-molecule compounds in PD models,which will shed light on a clue on exploiting more potential targeted small-molecule drugs tracking PD treatment in the near future.