Mechanisms of temozolomide resistance in glioblastoma-a comprehensive review
作者机构：Division of NeurosurgeryVirginia Tech Carilion School of MedicineRoanokeVA 24014USA Fralin Biomedical Research Institute at VTCRoanokeVA 24014USA Carilion Clinic-NeurosurgeryRoanokeVA 24014USA
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2021年第4卷第1期
页 面：17-43页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Glioblastoma temozolomide chemoresistance molecular mechanisms
摘 要：Glioblastoma(GBM)is the most common primary malignant brain tumor in adults and has an exceedingly low median overall survival of only 15 *** standard-of-care for GBM consists of gross total surgical resection followed by radiation with concurrent and adjuvant ***(TMZ)is the first-choice chemotherapeutic agent in GBM;however,the development of resistance to TMZ often becomes the limiting factor in effective *** O6-methylguanine-DNA methyltransferase repair activity and uniquely resistant populations of glioma stem cells are the most well-known contributors to TMZ resistance,many other molecular mechanisms have come to light in recent *** emerging mechanisms include the involvement of other DNA repair systems,aberrant signaling pathways,autophagy,epigenetic modifications,microRNAs,and extracellular vesicle *** review aims to provide a comprehensive overview of the clinically relevant molecular mechanisms and their extensive interconnections to better inform efforts to combat TMZ resistance.
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