Metabolic regulation in the immune response to cancer
作者机构：Department of Breast and Thyroid SurgeryRenmin Hospital of Wuhan UniversityWuhanHubei 430060P.R.China
出 版 物：《Cancer Communications》 (癌症通讯（英文）)
年 卷 期：2021年第41卷第8期
页 面：661-694页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：National Natural Science Foundation of China,Grant/Award Number:81471781 National Major Scientific Instruments and Equipment Development Projects,Grant/Award Number:2012YQ160203 Natural Science Foundation of Hubei Province,Grant/Award Number:Grant NO:2020CFA026
主 题：aging cancer immune response metabolism microbes obesity
摘 要：Metabolic reprogramming in tumor-immune interactions is emerging as a key factor affecting pro-inflammatory carcinogenic effects and anticancer immune ***,dysregulated metabolites and their regulators affect both cancer progression and therapeutic ***,we describe the molecular mechanisms through which microenvironmental,systemic,and microbial metabolites potentially influence the host immune response to mediate malignant progression and therapeutic *** summarized the primary interplaying factors that constitute metabolism,immunological reactions,and cancer with a focus on mechanistic ***,we discussed the possibility of metabolic interventions at multiple levels to enhance the efficacy of immunotherapeutic and conventional approaches for future anticancer treatments.
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