Hypoxia inducible factor and diffuse white matter injury in the premature brain: perspectives from genetic studies in mice

作     者：Fuzheng Guo Sheng Zhang Fuzheng Guo;Sheng Zhang

作者机构：Department of NeurologySchool of Medicinethe University of California Institute for Pediatric Regenerative Medicine(IPRM)ShrinerHospitals for ChildrenNorthern California 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第1期

页      面：105-107页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100202[医学-儿科学] 10[医学] 

基　　金：supported by NIH/NINDS(R21NS109790 and R01NS094559)(to FG) Shriners Hospitals for Children(85107-NCA-19 to FG,and 84307-NCAL to SZ)。 

主　　题：HIF1α HIF2α white 

摘      要：Hypoxia-inducible factors(HIFs)a re transcriptional regulators playing important roles in adapting various types of cells to physiological and pathological hypoxia cues.Three structurally related,oxygen-sensitive HIFαproteins have been identified(HIF1α,HIF2α,and HIF3α),among which HIF3αhas weak transcriptional capacity because of the absence of the C-terminal transactivation domain as present in HIF1αand HIF2α.