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Arabidopsis RPD3-like histone deacetylases form multiple complexes involved in stress response

多重建筑群在压力反应包含了的 Arabidopsis 象 RPD3 一样 histone deacetylases 形式

作     者:Chao Feng Xue-Wei Cai Yin-Na Su Lin Li She Chen Xin-Jian He Chao Feng;Xue-Wei Cai;Yin-Na Su;Lin Li;She Chen;Xin-Jian He

作者机构:College of Life SciencesBeijing Normal UniversityBeijing 100875China National Institute of Biological SciencesBeijing 102206China Tsinghua Institute of Multidisciplinary Biomedical ResearchTsinghua UniversityBeijing 10084China 

出 版 物:《Journal of Genetics and Genomics》 (遗传学报(英文版))

年 卷 期:2021年第48卷第5期

页      面:369-383页

核心收录:

学科分类:09[农学] 0903[农学-农业资源与环境] 

基  金:supported by the National Natural Science Foundation of China(32025003) by the National Key Research and Development Program of China(2016YFA0500801)from the Chinese Ministry of Science and Technology 

主  题:Histone deacetylase Complex Transcription Development Stress response HDA6 HDA19 

摘      要:The Arabidopsis thaliana RPD3-type histone deacetylases have been known to form conserved SIN3-type histone deacetylase complexes,but whether they form other types of complexes is ***,we perform affinity purification followed by mass spectrometry and demonstrate that the Arabidopsis RPD3-type histone deacetylases HDA6 and HDA19 interact with several previously uncharacterized proteins,thereby forming three types of plant-specific histone deacetylase complexes,which we named SANT,ESANT,and ***-seq indicates that the newly identified components function together with HDA6 and HDA19 and coregulate the expression of a number of ***6 and HDA19 were previously thought to repress gene transcription by histone *** find that the histone deacetylase complexes can repress gene expression via both histone deacetylation-dependent and-independent *** the mutants of histone deacetylase complexes,the expression of a number of stressinduced genes is up-regulated,and several mutants of the histone deacetylase complexes show severe retardation in *** that growth retardation is thought to be a trade-off for an increase in stress tolerance,we infer that the histone deacetylase complexes identified in this study prevent overexpression of stress-induced genes and thereby ensure normal growth of plants under nonstress conditions.

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