Circular RNAs:new biomarkers of chemoresistance in cancer

作     者：Jiaqi Wang Yi Zhang Lianyu Liu Ting Yang Jun Song Jiaqi Wang;Yi Zhang;Lianyu Liu;Ting Yang;Jun Song

作者机构：Department of General SurgeryThe Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002China Institute of Digestive Diseases of Xuzhou Medical UniversityXuzhou 221002China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2021年第18卷第2期

页      面：421-436页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported in part by the National Natural Science Foundation of China(Grant Nos.81702435 and 82073133) the Natural Science Foundation of Jiangsu Province(Grant Nos.BK20170264 and BK20191154) the Six Talent Peaks Project in Jiangsu Province(Grant No.WSW-050) 

主　　题：Circular RNA chemoresistance drug resistance cancer 

摘      要：Chemotherapeutics are validated conventional treatments for patients with advanced ***,with continual application of chemotherapeutics,chemoresistance,which is often predictive of poor prognosis,has gradually become a concern in recent *** RNAs(circ RNAs),a class of endogenous noncoding RNAs(nc RNAs)with a closed-loop structure,have been reported to be notable targets and markers for the prognosis,diagnosis,and treatment of many diseases,particularly *** dozens of studies have shown that circ RNAs play major roles in drug-resistance activity in tumors,the mechanisms by which circ RNAs affect chemoresistance have yet to be *** this review,we describe the detailed mechanisms of circ RNAs and chemotherapeutics in various cancers and summarize potential therapeutic targets for drug-resistant tumors.