Synthesis, Characterization and Crystal Structure of Cobalt(II) Complex of a Schiff Base Derived from Isoniazid and Pyridine-4-Carboxaldehyde
Synthesis, Characterization and Crystal Structure of Cobalt(II) Complex of a Schiff Base Derived from Isoniazid and Pyridine-4-Carboxaldehyde作者机构：Department of Chemistry Faculty of Science University of Buea Buea Cameroon Department of Inorganic Chemistry Faculty of Science University of Yaoundé 1 Yaoundé Cameroon Department of Chemistry Faculty of Science University of Douala Douala Cameroon The School of Chemistry De Montfort University Leicester UK The School of Chemistry and the School of Materials University of Manchester Manchester UK
出 版 物：《Crystal Structure Theory and Applications》 (晶体结构理论与应用（英文）)
年 卷 期：2019年第8卷第4期
页 面：45-56页
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
主 题：Pyridine Derivatives Cobalt(II) Complex Isonicotinoylhydrazone Pyridine-4-Carboxaldehyde Schiff Base Heterocyclic Compound X-Ray Structure
摘 要：A new hydrogen bonded Cobalt(II) Schiff base complex,?N’-(pyridine-4-carboxaldehyde) isonicotinoylhydrazone Cobalt(II), has been synthesized from isoniazid and pyridine-4-carboxaldehyde and characterized by IR spectroscopy, 1H-NMR, elemental analysis, TGA and single crystal X-ray structure determination. X-ray crystal structure analysis shows an octahedral complex with a metal centre coordinated to two ligand molecules through the pyridine nitrogen atoms and four water molecules and containing two nitrate groups as counter ions. The complex crystallizes in the monoclinic crystal system and P2(1)/n space group. The unit cell dimensions are: a = 7.2108(4) Å, b = 16.6020(9) Å, c = 13.0389(6) Å,α = 90°, β = 103.972(4)°, γ = 90°. The molecule is symmetrical about the cobalt centre as observed from the 1H-NMR and 13C-NMR and confirmed by the single crystal X-ray structure of the complex. Thermogravimetric analysis shows two steps decomposition of the complex to leave a metal oxide residue. The title compound is expected to be biologically active as one of the precursors (isoniazid) is a therapeutic agent with well-established clinical applications.
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