Safety of Transcranial Direct Current Electrical Stimulation in Dermatomyositis: A Case Report

作     者：Rafael Giovani Missé Luiz Felipe Adsuara de Sousa Lucas de Macedo dos Santos Abrahão Fontes Baptista Clarice Tanaka Julia Maria D’Andréa Greve Samuel Katsuyuki Shinjo 

作者机构：Division of RheumatologyFaculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil(BR) Department of Physical TherapySpeech Therapy and Occupational TherapyHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloSPBrazil(BR) Center for MathematicsComputing and CognitionUniversidade Federal de ABCSPBrazil(BR) Laboratory of Movement StudiesInstitute of Orthopedics and TraumatologyHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloBrazil(BR) 

出 版 物：《Open Journal of Rheumatology and Autoimmune Diseases》 (风湿病与自身免疫疾病期刊（英文）)

年 卷 期：2020年第10卷第2期

页      面：88-93页

学科分类：08[工学] 082302[工学-交通信息工程及控制] 0823[工学-交通运输工程] 

基　　金：Fundacao de Amparo a Pesquisa do Estado de Sao Paulo(FAPESP)#2019/12155-5 to RGM Conselho Nacional de Desenvolvimento Cientifico e Tecnologico(CNPq)303379/2018-9 to SKS Faculdade de Medicina da USP to SKS 

主　　题：Dermatomyositis Neuromodulation Safety Systemic Autoimmune Myopathies 

摘      要：Transcranial direct current stimulation (tDCS) has emerged as a nonpharmacological tool in physical rehabilitation. There have currently no studies that evaluated the safety and efficacy of tDCS in patients with dermatomyositis. Case-report: Three adult women with dermatomyositis were allocated randomly to intervention (i-tDCS, one patient) or not (sham-tDCS, two patients) of three consecutive days of tDCS and evaluated in four periods: before-tDCS (PRE), 15 minutes after-tDCS (0th POST), 15 days after-tDCS (15th POST), and 30 days after-tDCS (30th POST). The tDCS was safe throughout the protocol, without disease relapsing or adverse effects related to tDCS. Furthermore, the tDCS increased the muscle torque and total work of dominant and non-dominant elbow flexors in the patient with i-tDCS, when compared to two patients with sham-tDCS. Conclusions: The tDCS was safe and appeared to influence long-term strength in the limb of the patient with stable dermatomyo-sitis.