Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

作     者：Bowen Tan Quan Tang Yongjin Zhong Yali Wei Linfeng He Yanting Wu Jiabao Wu Jinfeng Liao Bowen Tan;Quan Tang;Yongjin Zhong;Yali Wei;Linfeng He;Yanting Wu;Jiabao Wu;Jinfeng Liao

作者机构：State Key Laboratory of Oral Diseases&National Clinical Research Centre for Oral Diseases&West China Hospital of StomatologySichuan UniversityChengduChina 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2021年第13卷第1期

页      面：17-32页

核心收录：

学科分类：1003[医学-口腔医学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation(31972925) the Sichuan Science and Technology Program(2020YJ0065) the Sichuan University Spark Project(2018SCUH0029) the State Key Laboratory of Oral Diseases Foundation(SKLOD202016) the Undergraduate Innovation and Entrepreneurship Training Program of Sichuan University(C2020108331). 

主　　题：tumour maxillofacial defect 

摘      要：Issues caused by maxillofacial tumours involve not only dealing with tumours but also repairing jaw bone defects.In traditional tumour therapy,the systemic toxicity of chemotherapeutic drugs,invasive surgical resection,intractable tumour recurrence,and metastasis are major threats to the patients’lives in the clinic.Fortunately,biomaterial-based intervention can improve the efficiency of tumour treatment and decrease the possibility of recurrence and metastasis,suggesting new promising antitumour therapies.In addition,maxillofacial bone tissue defects caused by tumours and their treatment can negatively affect the physiological and psychological health of patients,and investment in treatment can result in a multitude of burdens to society.Biomaterials are promising options because they have good biocompatibility and bioactive properties for stimulation of bone regeneration.More interestingly,an integrated material regimen that combines tumour therapy with bone repair is a promising treatment option.Herein,we summarized traditional and biomaterial-mediated maxillofacial tumour treatments and analysed biomaterials for bone defect repair.Furthermore,we proposed a promising and superior design of dual-functional biomaterials for simultaneous tumour therapy and bone regeneration to provide a new strategy for managing maxillofacial tumours and improve the quality of life of patients in the future.