Cytochrome-c aptamer functionalized Pt nanoclusters for enhanced chemodynamic therapy

作     者：Bo Feng Dan Zhao Yaowei Peng Fu Wang Bo Feng;Dan Zhao;Yaowei Peng;Fu Wang

作者机构：Med-X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240P.R.China 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2021年第4卷第4期

页      面：64-71页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：This work is supported by the Cross Research Fund of Biomedical Engineering of Shanghai Jiao Tong University(YG2019QNA43) 

主　　题：chemodynamic therapy Pt nanoclusters cytochrome c aptamer 

摘      要：Catalysis-based chemodynamic therapy(CDT)is an emerging cancer treatment strategy which uses a Fenton-like reaction to kill tumor cells by catalyzing endogenous hydrogen peroxide(H_(2)O_(2))into a toxic hydroxyl radical(·OH).The performance of CDT is greatly dependent on PDT ***,mitochondria-targeting Pt nanoclusters were synthesized using cytochrome c aptamer(CytcApt)as *** obtained CytcApt-PtNCs can *** by H_(2)O_(2)under the acidic ***,CytcApt-PtNCs could kill 4T1 tumor cells in a pH-dependent manner,but had no side effect on normal 293T ***,CytcApt-PtNCs possess excellent therapeutic effect and good biosafety,indicating their great potential for CDT.