Insights into Plasmodium and SARS-CoV-2 co-infection driven neurological manifestations

作     者：Omkar Indari Budhadev Baral Kartik Muduli Ambika Prasad Mohanty Natabar Swain Nirmal Kumar Mohakud Hem Chandra Jha 

作者机构：Department of Biosciences and Biomedical EngineeringIndian Institute of Technology IndoreIndia School of BiotechnologyKIIT Deemed UniversityOdishaIndia Department of MedicineKalinga Institute of Medical SciencesKIIT Deemed UniversityOdishaIndia Department of PediatricsKalinga Institute of Medical SciencesKIIT Deemed UniversityOdishaIndia 

出 版 物：《Biosafety and Health》 (生物安全与健康（英文）)

年 卷 期：2021年第3卷第4期

页      面：230-234页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by Council for Scientific and Industrial Research[Grant no 37(1693)/17/EMR-II] Department of Science and Technology as Ramanujan fellowship[Grant no.SB/S2/RJN-132/20/5] 

主　　题：Malaria Plasmodium falciparum SARS-CoV-2 COVID-19 Co-infection Cerebral malaria Neurological manifestation 

摘      要：In malaria-endemic regions,people often get exposed to various pathogens simultaneously,generating coinfection *** such scenarios,overlapping symptoms pose serious diagnostic *** delayed diagnosis may lead to an increase in disease severity and catastrophic *** coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has affected various areas globally,including malaria-endemic *** Plasmodium and SARS-CoV-2 co-infection and its effect on health are yet *** present a case report of a previously healthy,middle-aged individual from the malaria-endemic area who suffered SARS-CoV-2 and Plasmodium falciparum *** patient developed severe disease indications in a short time *** patient showed neurological symptoms,altered hematological as well as liver-test parameters,and subsequent death in a narrow time *** hereby discuss the various aspects of this case regarding treatment and hematological ***,we have put forward perspectives related to the mechanism behind severity and neurological symptoms in this fatal parasite-virus co-infection *** malaria-endemic regions,due to overlapping symptoms,suspected COVID-19 patients should also be monitored for diagnosis of malaria without any *** SARS-CoV-2 and Plasmodium co-infection could increase the disease severity in a short time *** treatment,dexamethasone may not help in severe cases having malaria as well as COVID-19 positive status and needs further exploration.