Evolving Models and Tools for Microglial Studies in the Central Nervous System

作     者：Yang Zhang Donghong Cui Yang Zhang;Donghong Cui

作者机构：Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai200030China Shanghai Key Laboratory of Psychotic DisordersShanghai201108China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2021年第37卷第8期

页      面：1218-1233页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：the National Key Research and Development Program of China(2017YFC0909200) the National Natural Science Foundation of China(81671336) Shanghai Key Laboratory of Psychotic Disorders(YG2016ZD06) the Shanghai Mental Health Center(2019-YJ06) 

主　　题：Microglial cell lines Primary microglia Induced microglia-like cells Transgenic mice Human-mouse chimeric models Microglial replacement Single-cell technology In vivo imaging 

摘      要：Microglia play multiple roles in such processes as brain development,homeostasis,and *** to their diverse mechanisms of functions,the complex sub-classifications,and the large differences between different species,especially compared with humans,very different or even opposite conclusions can be drawn from studies with different research *** choice of appropriate research models and the associated tools are thus key ingredients of studies on *** are the most commonly used animal *** this review,we summarize in vitro and in vivo models of mouse and human-derived microglial research models,including microglial cell lines,primary microglia,induced microglia-like cells,transgenic mice,human-mouse chimeric models,and microglial replacement *** also summarize recent developments in novel single-cell and in vivo imaging *** hope our review can serve as an efficient reference for the future study of microglia.