Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

作     者：Wenjing Yang Yingzi Cong 

作者机构：Department of Microbiology and ImmunologyUniversity of Texas and 2Department of PathologyUniversity of Texas Medical BranchGalvestonTXUSA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2021年第18卷第4期

页      面：866-877页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by NIH grants DK105585,DK112436,DK125011,AI150210,and DK124132 the University of Texas System STARs award(Y.C.) supported by the James W.McLaughlin Fellowship Fund,UTM B(W.Y.) 

主　　题：gut microbiota metabolites T cells B cells autoimmune diseases 

摘      要：The gut microbiota has a critical role in the maintenance of immune *** in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in many immune-related inflammatory *** metabolites can be produced by gut microbiota from dietaiy components or by the host and can be modified by gut bacteria or synthesized de novo by gut *** microbiota-derived metabolites influence a plethora of immune cell responses,including T cells,B cells,dendritic cells,and *** e of these metabolites are involved in the pathogenesis of immune-related inflammatory diseases,such as inflammatory bowel diseases,diabetes,rheumatoid arthritis,and systemic lupus ***,we review the role of microbiota-derived metabolites in regulating the functions of different immune cells and the pathogenesis of chronic immune-related inflammatory diseases.