Reprogramming Restores Vision in Mice by Changing DNA Methylation

作     者：Jiali Shi Shanshan Sun Yongjie Wang Zhihui Huang Jiali Shi;Shanshan Sun;Yongjie Wang;Zhihui Huang

作者机构：College of PharmacySchool of Medicineand Department of NeurosurgeryThe Affiliated HospitalHangzhou Normal UniversityHangzhou 311121China Key Laboratory of Elemene Class Anti-Cancer Chinese MedicinesEngineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou 311121China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2021年第37卷第10期

页      面：1526-1528页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：by the Natural Science Foundation of Zhejiang Province(LR18C090001) the National Natural Science Foundation of China(92049104,81801102,and 82071230) the Research Start-up Project by Hangzhou Normal University(4125C5021920453 and 4125C50220204109) 

主　　题：programming differentiated specialized 

摘      要：Cell reprogramming is the process of reverting mature,specialized cells into induced pluripotent stem *** also refers to the erasure and re-establishment of epigenetic markers during the development of mammalian germ cells,such as DNA methylation[1].At present,reprogramming mainly refers to two processes:the process of reverting differentiated cells to a pluripotent state,and the process of transforming one type of differentiated cell into another[2].Reprogramming mainly includes induced pluripotent stem(iPS)cells,direct transdifferentiation,and indirect lineage conversion.