多发性硬化症与自身免疫性疾病:意大利东北部人群流行病学与HLA-DR之间的联系
Multiple sclerosis and autoimmune diseases: Epidemiology and HLA-DR association in North-east Italy作者机构：Multiple Sclerosis Centre of the Veneto Region First Neurology Clinic - Dept. of Neurosciences University of Padova Via Giustiniani 5 35128 - Padova Italy Dr.
出 版 物：《世界核心医学期刊文摘(神经病学分册)》 (Digest of the World Core Medical Journals.Clinical Neurology)
年 卷 期：2006年第10期
页 面：25-26页
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
主 题：自身免疫性疾病 一级亲属 患者 家族 自身免疫病 家系 多发性硬化症 HLA-DR 南欧 意大利
摘 要：An autoimmune background is thought to characterize the families of multiple sclerosis (MS) patients, but disease patterns and HLA- DR association seem to vary considerably among different ethnic groups. We investigated the prevalence of autoimmune diseases in 245 MS patients and 245 age- and sex- matched normal controls (NC), originating from and living in North- east Italy, and their first degree relatives, using a casecontrol method. Further, HLA- DRB1 expression was analysed in MS and NC. The following significant findings were observed: 1) a significant excess of autoimmunity in first- degree relatives of MS patients (p = 0.000), 2) an association of MS with Type 1 diabetes mellitus (T1DM) (p = 0.02), 3) an increase in DR4 expression (namely DRB1 0401) in MS patients from families with multiple autoimmune pathology compared with reference MS patients (p=0.02) and NC (p=0.01).We conclude that the risk of autoimmune disease is higher in first- degree relatives of MS patients and that disease association and HLA- DR expression in North- east Italy differs from other geographic regions of Europe.
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