Multifactorial role of HIV-Vpr in cell apoptosis revealed by a naturally truncated 54aa variant

作     者：Ling Du Cui-Song Wu Jun Sun Tong Yu Pan-Pan Lyu San-Feng Han Chao Qiu Zhe-Feng Meng Du Ling;Wu Cui-Song;Sun Jun;Yu Tong;Lyu Pan-Pan;Han San-Feng;Qiu Chao;Meng Zhe-Feng

作者机构：Key Laboratory of digestive cancer full cycle monitoring and precise intervention of Shanghai Municipal Health CommissionMinhang HospitalFudan UniversityShanghai 201199China Department of infectionthe Third People’s Hospital of Zhenjiang CityZhenjiangJiangsu 212021China Institutes of Biomedical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China. 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第7期

页      面：845-847页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Shanghai Natural Science Foundation China(No.17ZR1425200)。 

主　　题：Vpr apoptosis HIV 

摘      要：Although antiretroviral therapy(ART)is effective at suppressing the human immunodeficiency virus type 1(HIV-1)replication,HIV-1 infection is still a global public health problem.HIV-1 accessory protein viral protein R(Vpr)is a multifunctional protein with a primary role in regulating cellular apoptosis.[1]The amino acid(aa)positions 52-96 in the C-terminus of Vpr were identified as the apoptosis-regulating domain.[2,3]In this study,we found a natural Vpr variant truncated at the 54 aa position(*54Vpr)from HIV patients in the acquired immune deficiency syndrome(AIDS)phase that mediated both pro-and antiapoptotic cellular effects by interacting with distinct adenine nucleotide translocator(ANT)isoforms.A novel apoptosis-regulating domain was further identified in the 23-37 aa position in the N-terminus of Vpr.