Immune responses to SARS-CoV-2 infection in Humans and ACE2 humanized mice

作     者：Airu Zhu Zhao Chen Yanqun Wang Qiuhui Zeng Jing Sun Zhen Zhuang Fang Li Jingxian Zhao Jincun Zhao Nanshan Zhong 

作者机构：State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China 

出 版 物：《Fundamental Research》 (自然科学基础研究（英文版）)

年 卷 期：2021年第1卷第2期

页      面：124-130页

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：the National Key Research and Development Program of China(2018YFC1200100,2018ZX10301403,2020YFC0842400) National Natural Science Foundation of China(82025001) Ministries of Science and Technology of China,Education of Guangdong Province(2020B1111330001,2020A111128008,2020B1111320003,2020A0505100063,2020KZDZX1158,B195001248,2020A1515010911) National Key Technology R&D Program(2018YFC1311900) Guangdong Science and Technology Foundation(2019B030316028) State Key Laboratory of Respiratory Disease(SKLRD-QN-201912 and SKLRD-Z-202007) Guangzhou Medical University High-level University Innovation Team Training Program(Guangzhou Medical University releasedNo.159). 

主　　题：SARS-CoV-2 Innate immune response Humoral immune responses T cell response Mouse model 

摘      要：The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represents a major public health threat worldwide.Insight into protective and pathogenic aspects of SARS-CoV-2 immune responses is critical to work out effective therapeutics and develop vaccines for controlling the disease.Here,we review the present literature describing the innate and adaptive immune responses including innate immune cells,cytokine responses,antibody responses and T cell responses against SARS-CoV-2 in human infection,as well as in AEC2-humanized mouse infection.We also summarize the now known and unknown about the role of the SARS-CoV-2 immune responses.By better understanding the mechanisms that drive the immune responses,we can tailor treatment strategies at specific disease stages and improve our response to this worldwide public health threat.