Relationship Between Serum Testosterone,Leptin,Interleukin-6(il-6)Level and Insulin Sensitivity in Non-obese and Obese Male Subjects in Magway Region,Myanmar
作者机构：Department of PhysiologyUniversity of Medicine 1YangonMyanmar Department of PhysiologyUniversity of MedicineMagwayMagway Regional DivisionThe Republic of Union of Myanmar Department of PhysiologyUniversity of Medicine 2YangonThe Republic of Union of Myanmar
出 版 物：《Journal of Endocrinology Research》 (内分泌系统研究（英文）)
年 卷 期：2020年第2卷第2期
页 面：9-15页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Leptin Testosterone IL-6 NHOMA-IR Obesity
摘 要：Objective:To determine the relationship between insulin resistance and related variables(serum testosterone,interleukin(IL-6)and leptin level)in obese and non-obese healthy ***:Community-based crosssectional,analytic study was undertaken in 60 subjects for each obese group(BMI≥30.0 kg/m2)and non-obese group(BMI 18.5 to 24.9 kg/m2)(age;18-45 years)residing in Magway Township from December 2016 to December *** insulin,testosterone,IL-6 and leptin levels were measured by enzyme linked immunoassay,and serum fasting glucose was measured by glucose oxidase *** sensitivity was calculated by HOMA formula(Homeostatic Model Assessment).Results:HOMA-IR,serum leptin and IL-6 level were significantly higher in obese group while serum testosterone level was significantly lower in obese *** was a significantly correlation between HOMA-IR with leptin(r=0.306,p=0.001),IL-6(r=0.237,p=0.009)and testosterone(r=-0.209,p=0.02).Moreover,serum leptin was significantly and positively correlated with IL-6(r=0.391,p0.001)while serum testosterone was significantly and negatively correlated with leptin(r=-0.408,p0.001),and IL-6(r=-0.34,p0.001).Conclusions:Obese men are more likely to have low testosterone,high inflammatory markers leptin and Il-6,which were associated with decreased insulin sensitivity.
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