In vitro and in vivo antibacterial activity of graphene oxidemodified porous TiO_(2) coatings under 808-nm light irradiation

作     者：Mao-Zhou Chai Mei-Wen An Xiang-Yu Zhang Paul-KChu 

作者机构：College of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Laboratory of Biomaterial Surfaces&InterfacesInstitute of New Carbon MaterialsTaiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Bone and Soft Tissue Injury RepairDepartment of OrthopedicsSecond Hospital of Shanxi Medical UniversityTaiyuan 030024China Department of PhysicsDepartment of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongKowloonHong Kong 999077China 

出 版 物：《Rare Metals》 (稀有金属（英文版）)

年 卷 期：2022年第41卷第2期

页      面：540-545页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 080503[工学-材料加工工程] 0806[工学-冶金工程] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：This work was financially supported by the National Natural Science Foundation of China(No.31870934) the Major Projects in Research and Development of Shanxi(No.201803D421090) City University of Hong Kong Strategic Research Grant(No.7005264) Guangdong-Hong Kong Technology Cooperation Funding Scheme GHP/085/18SZ(No.CityU 9440230) 

主　　题：Antibacterial activity Graphene oxide(GO) Porous TiO_(2)coating Photo-therapy 

摘      要：Bio-inertness and post-surgery infection on titanium(Ti)are the main causes of failure of biomedical implants in ***-infrared(NIR)photoactivated antibacterial therapy including photothermal and photodynamic therapies has attracted increasing attention due to the high bactericidal efficiency and little side *** micro-arc oxidation(MAO)is an effective method to improve the biological activity of Ti implants,the porous TiO_(2)coatings prepared by MAO do not respond to near-infrared(NIR)light to kill bacteria by the photothermal and photodynamic *** this work,graphene oxide(GO)-modified TiO_(2)coatings(TiO_(2)/GO)are prepared on Ti to improve the photothermal and photodynamic ability of the MAO *** TiO_(2)/GO coatings exhibit excellent antibacterial activity both in vitro and in vivo against Streptococcus mutans(***)under 808-nm NIR light irradiation due to the synergistic effects rendered by hyperthermia and reactive oxygen species(ROS).The NIR light-responsive antibacterial MAO coatings have large potential in combating implant-associated infections in clinical applications.