Ribosomal protein S26 serves as a checkpoint of T-cell survival and homeostasis in a p53-dependent manner

作     者：Chaojia Chen Jiali Peng Shuaiya Ma Yuming Ding Tao Huang Shigang Zhao Lifen Gao Xiaohong Liang Chunyang Li Chunhong Ma 

作者机构：Key Laboratory for Experimental Teratology of the Ministry of Education and Department of ImmunologySchool of Basic Medical ScienceShandong UniversityJinanShandongPR China School of MedicineShandong UniversityJinanShandongPR China Center for Reproductive MedicineSchool of MedicineCheeloo College of MedicineShandong UniversityNational Research Center for Assisted Reproductive Technology and Reproductive GeneticsKey Laboratory of Reproductive Endocrinology of the Ministry of EducationShandong Provincial Clinical Medicine Research Center for Reproductive HealthJinanShandongPR China Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Histology and EmbryologySchool of Basic Medical ScienceShandong UniversityJinanShandongPR China Key Laboratory of Infection and Immunity of Shandong ProvinceSchool of Basic Medical ScienceShandong UniversityJinanShandongPR China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2021年第18卷第7期

页      面：1844-1846页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by Taishan Scholarship(No.tspd20l81201) the Major Basic Research Project of Shandong Natural Science Foundation ZR2020ZD12 the National Natural Science Foundation of China(Key program 81830017 to C.M Grant 31600714 to CL.) the China Postdoctoral Science Foundation(Grants 2016M592193 and 2018M642660 to C.L.) the Young Elite Scientist Sponsorship Program by Cast(Grant YESS20160077 to C.L) the National Postdoctoral Program for Innovative Talents(Grant BX201700147 to C.L.) the Young Scholars Program of Shandong University(to C.L.) 

主　　题：homeostasis p53 finding 

摘      要：Ribosomal proteins(RPs),which play critical roles in ribosome assembly and protein translation,have been proven to be associated with important physiological and pathological processes,including the regulation of T-cell development and immune-related diseases.1,2,3 A recent study reported that ribosomal protein S26(Rps26),which is a Diamond–Blackfan anemia-associated RP located in the 40S subunit that controls oocyte growth,4,5 may influence multiple different immune phenotypes.6 Moreover,a SNP in the 5′UTR of the Rps26 gene in CD4^(+)and CD8+T cells was implicated in several autoimmune diseases.7 However,the function of Rps26 in T lymphocytes remains ***,we found that Rps26 was highly expressed in T *** examined a T-cell-specific Rps26 knockout mouse model and reported for the first time that ablation of Rps26 in T cells not only impairs peripheral T-cell homeostasis but also leads to T-cell developmental arrest in the ***,Rps26 critically regulates T-cell survival in a p53-dependent *** findings reveal the indispensable role of the Rps26-p53 axis in T-cell development and homeostasis.