COVID-19 combined with liver injury:Current challenges and management

作     者：Man-Ling Deng Yong-Jun Chen Mei-Ling Yang Yi-Wen Liu Hui Chen Xiao-Qing Tang Xue-Feng Yang 

作者机构：Department of GastroenterologyThe Affiliated Nanhua HospitalHengyang Medical CollegeUniversity of South ChinaHengyang 421002Hunan ProvinceChina Department of NeurologyThe Affiliated Nanhua HospitalHengyang Medical CollegeUniversity of South ChinaHengyang 421002Hunan ProvinceChina Department of OncologyThe Affiliated Nanhua HospitalHengyang Medical CollegeUniversity of South ChinaHengyang 421002Hunan ProvinceChina Institute of Clinical MedicineThe First Affiliated HospitalHengyang Medical CollegeUniversity of South ChinaHengyang 421001Hunan ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2021年第9卷第15期

页      面：3487-3497页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Novel Coronavirus Pneumonia Emergency Project of University of South China,No.2020-15 and No.2020-25 Fund Project of Hengyang City for Prevention and Control of COVID-19,No.202010031577 and Key Research and Development Program of Hunan Province,No.2020SK3039 and No.2020SK3040 

主　　题：SARS-CoV-2 COVID-19 Liver function Liver injury Pathogenesis Treatment 

摘      要：Coronavirus disease 2019(COVID-19)combined with liver injury has become a very prominent clinical *** to the lack of a clear definition of liver injury in patients with COVID-19,the different selection of evaluation parameters and statistical time points,there are the conflicting conclusions about the incidence rate in different *** mechanism of COVID-19 combined with liver injury is complicated,including the direct injury of liver cells caused by severe acute respiratory syndrome coronavirus 2 replication and liver injury caused by cytokines,ischemia and hypoxia,and *** addition,underlying diseases,especially chronic liver disease,can aggravate COVID-19 liver *** the treatment of COVID-19 combined with liver injury,the primary and basic treatment is to treat the etiology and pathogenesis,followed by support,liver protection,and symptomatic treatment according to the clinical classification and severity of liver *** article evaluates the incidence,pathogenesis and prevention and treatment of COVID-19 combined with liver injury,and aims to provide countermeasures for the prevention and treatment of COVID-19 combined with liver injury.