Targeting circular RNAs as a therapeutic approach: current strategies and challenges

作     者：Alina T.He Jinglei Liu Feiya Li Burton B.Yang Alina T.He;Jinglei Liu;Feiya Li;Burton B.Yang

作者机构：Sunnybrook Research InstituteTorontoONCanada Department of BioinformaticsATCGene IncGuangzhouChina Department of Laboratory Medicine and PathobiologyUniversity of TorontoTorontoONCanada 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第6期

页      面：1718-1731页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：supported by grants from Canadian Institutes of Health Research to BBY(PJT-153105 PJT-155962 and PJT-166107) 

主　　题：therapeutic specificity circular 

摘      要：Significant progress has been made in circular RNA(circRNA)research in recent *** evidence suggests that circRNAs play important roles in many cellular processes,and their dysregulation is implicated in the pathogenesis of various *** are highly stable and usually expressed in a tissue-or cell type-specific ***,they are currently being explored as potential therapeutic ***-of-function and loss-of-function approaches are typically performed using circRNA expression plasmids and RNA interference-based strategies,*** strategies have limitations that can be mitigated using nanoparticle and exosome delivery ***,recent developments show that the cre-lox system can be used to knockdown circRNAs in a cell-specific *** still in the early stages of development,the CRISPR/Cas13 system has shown promise in knocking down circRNAs with high specificity and *** this review,we describe circRNA properties and functions and highlight their significance in *** summarize strategies that can be used to overexpress or knockdown circRNAs as a therapeutic ***,we discuss major challenges and propose future directions for the development of circRNA-based therapeutics.