Magnetoresponsive nanozyme:magnetic stimulation on the nanozyme activity of iron oxide nanoparticles

作     者：Yuan He Xiaoyong Chen Ye Zhang Yanyun Wang Mengyao Cui Galong Li Xiaoli Liu Haiming Fan Yuan He;Xiaoyong Chen;Ye Zhang;Yanyun Wang;Mengyao Cui;Galong Li;Xiaoli Liu;Haiming Fan

作者机构：Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of EducationCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China Key Laboratory of Resource Biology and Biotechnology in Western ChinaMinistry of Education/School of MedicineNorthwest UniversityXi’an 710069China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2022年第65卷第1期

页      面：184-192页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China(81771981,82072063,and 31400663) the National Natural Science Foundation for Young Scholars of China(31901003) Shaanxi Province Funds for Distinguished Young Scholars(202031900097) Shaanxi Science and Technology Department(2019KW-078) the Postdoctoral Science Foundation of China(2020M673631XB) 

主　　题：magnetoresponsive nanozyme magnetic stimulation specific absorption rate activity regulation 

摘      要：The iron oxide nanoparticles(IONPs)that combine the nanozyme activity and magnetothermal properties have attracted significant interest for various biomedical ***,the effect of magnetic stimulation in fine-tuning the nanozyme activities remains ***,we have constructed a series of IONPs with different magneto-thermal conversion abilities,and systematically study the effect of magnetic field stimulation on the peroxidase(POD)activity of *** results show that POD activity is effectively amplified via an in situ alternating magnetic field(AMF)stimulation with no solution temperature rise,and the degree of activity enhancement is closely related to the magnetic heating ability of the IONPs,confirming the origin of activity enhancement arises from the local magnetothermal *** the first report to prove magnetothermal regulation on nanozyme activity and to shed lights on the underlying correlation between activity enhancement and the intrinsic specific absorption rate(SAR),this work is expected to provide important support for future design of new magnetoresponsive nanozymes in various practical applications.