Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice

作     者：Li Sun Li Bao Dorji Phurbu Shanshan Qiao Shanshan Sun Yangzom Perma Hongwei Liu Li Sun;Li Bao;Dorji Phurbu;Shanshan Qiao;Shanshan Sun;Yangzom Perma;Hongwei Liu

作者机构：State Key Laboratory of MycologyInstitute of MicrobiologyChinese Academy of SciencesBeijing 100864China Savaid Medicine SchoolUniversity of Chinese Academy of SciencesBeijing 100864China Beijing Shijitan HospitalCapital Medicinal UniversityBeijing 100864China Tibet Plateau Institute of BiologyLhasa 850000China School of Life SciencesUniversity of Science and Technology of ChinaHefei 230026China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2021年第10卷第4期

页      面：442-451页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 083202[工学-粮食、油脂及植物蛋白工程] 

基　　金：This study was supported by the Project of Science and Technology Department of Tibet(XZ201901-GB-19). 

主　　题：Sarcodon leucopus Polyphenolic alkaloids Metabolic syndrome Gut microbiota Ruminococcaceae 

摘      要：A polyphenolic alkaloid-enriched extract(PAE)was prepared from the fruiting bodies of a wild edible mushroom Sarcodon leucopus.Oral administration of PAE reduced hyperglycemia,hyperlipidemia,hepatic steatosis,and LPS-related infl ammation in high fat diet-induced obese(DIO)mice.Furthermore,we show that PAE produces taxonomic and predicted functional changes in the gut microbiome of DIO mice.A signifi cant decrease in the family of Ruminococcaceae,especially the secondary bile acid-producing bacteria of Intestinimonas and Anaerotruncus,is detected in the gut microbiome of PAE-treate mice.Accordingly,reductions of deoxycholic acid and lithocholic acid are found in the feces of PAE-treated DIO mice,which benefi ts for the intestinal integrity and the reduction of infl ammation.A gut microbiota related mechanism for the anti-metabolic syndrome effects of the PAE is proposed.We suppose the polyphenolic alkaloid extract from S.leucopus be a new and benefi cial prebiotic regulating glucose and lipid metabolisms.