Occupational Radiation Exposure and Changes in Thyroid Hormones in a Cohort of Chinese Medical Radiation Workers

作     者：GUO Qi Shan RUAN Ping HUANG Wei Xu HUANG Dai Zheng QIU Jia Chu GUO Qi Shan;RUAN Ping;HUANG Wei Xu;HUANG Dai Zheng;QIU Jia Chu

作者机构：School of Public HealthGuangdong Pharmaceutical UniversityGuangzhou 510310GuangdongChina Guangdong Province Engineering&Technology Research Center for Medical 3D Printer and Personalized MedicineGuangzhou 510006GuangdongChina Department of Biomedical EngineeringGuangdong Pharmaceutical UniversityGuangzhou 510006GuangdongChina Guangdong Prevention and Treatment Center for Occupational DiseaseGuangzhou 510300GuangdongChina Department of Biomedical EngineeringGuangxi Medical UniversityNanning 530021GuangxiChina 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2021年第34卷第4期

页      面：282-289页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100402[医学-劳动卫生与环境卫生学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China Guangdong Science and Technology Program[2016A020215162] Innovating Strong School Project of Guangdong Pharmaceutical University。 

主　　题：Occupational radiation Thyroid function Cohort 

摘      要：Objective This study aimed to evaluate the association between occupational radiation exposure and changes in thyroid hormone levels among medical radiation workers.Methods This retrospective cohort study included 2,946 radiation workers from 20 Guangzhou hospitals.Data on general characteristics,participant radiation dosimetry,and thyroid function test results[thyroid-stimulating hormone(TSH),triiodothyronine(T3),and thyroid hormone(T4)]were extracted from dosimetry and medical records.The generalized estimating equation was used to evaluate the trend of changes in thyroid hormone levels over time and was adjusted for age,gender,and occupation.Results The average annual effective dose was very low and showed a general downward trend.During the follow-up period,changes in T3 and T4 levels among radiation workers were-0.015[95% confidence interval(CI)-0.018 to-0.012]nmol/L per year and-2.294(95%CI-2.426 to-2.162)nmol/L per year,respectively.Thyroid hormone levels were significantly different between males and females.T3 levels in the group of upper quartile of dose were significantly higher than in the lower quartile group(P=0.006).No significant decreased trend in thyroid hormone levels was observed with increasing average effective doses.Conclusion Thyroid hormone secretion might be affected even in low-dose radiation exposure environments.