Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats

作     者：Fan Zhang Ken K.L.Yung Chi KongYeung Fan Zhang;Ken K.L.Yung;Chi KongYeung

作者机构：Division of Science and TechnologyBNU-HKBU United International CollegeZhuhaiGuangdongChina Department of BiologyHong Kong Baptist UniversityHong KongChina Animal Science DepartmentCalifornia Polytechnic State UniversitySan Luis ObispoCaliforniaUSA 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2021年第10卷第3期

页      面：327-334页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 0822[工学-轻工技术与工程] 082203[工学-发酵工程] 

基　　金：The technical assistance provided by the staff at HKBU animal facilities is grateful acknowledged.This project was funded by the National Natural Science Foundation of China(award no.31171664). 

主　　题：Iron Non-digestible oligosaccharides Short-chain fatty acids Prebiotics Rat 

摘      要：Prebiotics may enhance iron absorption,and one plausible mechanism involves the production of shortchain fatty acids(SCFA)in the colon by intestinal microflora.The objectives of this study were to determine the effects of common commercially-available prebiotics including fructooligosaccharide(FOS),inulin,FOS-inulin mixture,galactooligosaccharide(GOS),and lactulose on the iron status of anemic rats,and to monitor changes in the production of colonic SCFA.Anemic Sprague-Dawley rats receiving a lowiron diet(12μg Fe/g diet)were supplemented with or without prebiotics(5%m/V in drinking water)for 5 weeks.Hemoglobin concentration in rats supplemented with GOS after 3 weeks(4.3 g/dL)was significantly higher than rats without supplementation(3.7 g/dL),while FOS also significantly increased hemoglobin concentration after 4 weeks(4.1 g/dL vs.3.7 g/dL).All other prebiotics showed no effects.Anemic rats showed lower overall SCFA production in the colon than normal rats,and only FOS signifi cantly increased the production of the three main SCFA(acetic acid,propionic acid and isobutyric acid)identifi ed in anemic rats,with other prebiotics showing no noticeable trends.Our results suggest that GOS and FOS may slightly improve iron status of anemic rats,but the role of SCFA in the colon is not clear.