Novel CD-MOF NIR-II fluorophores for gastric ulcer imaging

作     者：Yishen Liu Yuzhen Yuzhen Tian Tian Wumei Wang Jinxia Nong Xue Qiao Fuchun Xu Jianfeng Gao Xuechuan Hong Yishen Liu;Yuzhen Yuzhen;Tian Tian;Wumei Wang;Jinxia Nong;Xue Qiao;Fuchun Xu;Jianfeng Gao;Xuechuan Hong

作者机构：State Key Laboratory of VirologyCollege of ScienceInnovation Center for Traditional Tibetan Medicine Modernization and Quality ControlMedical CollegeTibet UniversityLhasa 850000China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(MOE)Hubei Province Engineering and Technology Research Center for Fluorinated PharmaceuticalsWuhan University School of Pharmaceutical SciencesWuhan 430071China Shenzhen Institute of Wuhan UniversityWuhan 430071China Center for Animal ExperimentWuhan UniversityShenzhen 518057China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第10期

页      面：3061-3065页

核心收录：

学科分类：1002[医学-临床医学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 070302[理学-分析化学] 0703[理学-化学] 10[医学] 

基　　金：partially supported by the National Key R&D Program of China(No.2020YFA0908800) National Nature Science Foundation of China(No.81773674) Shenzhen Science and Technology Research Grant(No.JCYJ20190808152019182) Hubei Province Scientific and Technical Innovation Key Project(No.2020BAB058) the Applied Basic Research Program of Wuhan Municipal Bureau of Science and Technology(No.2019020701011429) the Local Development Funds of Science and Technology Department of Tibet(No.XZ202001YD0028C) Tibet Autonomous Region Science and Technology Plan Project Key Project(No.XZ201901-GB-11) the Natural Science Foundation of Hubei(No.2019CFB679) the Health Commission of Hubei Province Scientific Research Project(No.WJ2021Q031) the Fundamental Research Funds for the Central Universities(No.ZNJC201931) 

主　　题：Gastric ulcer NIR-II bioimaging Cyclodextrin metal-organic frameworks Real time Diagnose 

摘      要：Gastric ulcers are one of the most common stomach diseases that often accompanied by inflammation,congestion,edema,scar tissue formation,and pyloric *** endoscopy and X-ray analysis of the upper GI tract have become the diagnostic procedure of choice for ***,conventional diagnosis technology is either invasive or ***,a novel CD-MOF NIR-II fluorophore(GPs-CH1055)was *** relative fluorophore intensity was largely consistent at various media and pH buffers,and it can swell into gel particles in solvents and be completely expelled from the gastrointestinal tract without being ***-CH1055 has been further evaluated in vivo,and exhibited strong retention effect on the gastric ulcer sites,bright NIR-II signals with high spatial and temporal ***,GPs-CH1055 shows great promise for realizing real-time gastric ulcer imaging and diagnosis.