Demographic and Clinical Characteristics of 63 Children with Myelomeningoceles

作     者：Youssouf Sogoba Seybou Hassane Diallo Issa Amadou Boubacar Sogoba Moussa Diallo Benoi Kamaté Daouda Mariko Coulibaly Oumar Quenum Kisito Hawa Diall Leonie Diakité Salimata Diallo Belco Maiga Fousseyni Traoré Karamoko Sacko Oumar Diallo Drissa Kanikomo Youssoufa Maiga Youssouf Sogoba;Seybou Hassane Diallo;Issa Amadou;Boubacar Sogoba;Moussa Diallo;Benoi Kamaté;Daouda Mariko;Coulibaly Oumar;Quenum Kisito;Hawa Diall;Leonie Diakité;Salimata Diallo;Belco Maiga;Fousseyni Traoré;Karamoko Sacko;Oumar Diallo;Drissa Kanikomo;Youssoufa Maiga

作者机构：Department of Neurosurgery Hô pital Gabriel Touré Bamako Mali Department of Neurology Hô pital Gabriel Touré Bamako Mali Department of Pediatric Surgery Hô pital Gabriel Touré Bamako Mali Department of Neurosurgery Hô pital du Mali Bamako Mali Department of Neurosurgery University Hospital of Parakou Parakou Benin Department of Pediatrics Hô pital Gabriel Touré Bamako Mali 

出 版 物：《Open Journal of Modern Neurosurgery》 (现代神经外科学进展（英文）)

年 卷 期：2021年第11卷第2期

页      面：59-64页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Myelomeningocele Neural Tube Defects Hydrocephalus 

摘      要：Background: Myelomeningocele (MMC) is the most common neural tube defect (NTD) characterized by the extrusion of the spinal cord into a sac filled with cerebrospinal fluid, resulting in lifelong disability. In the general population, the incidence of MMC ranges from 0.3 to 4.5/10,000 births. Live born infants with myelomeningocele have a death rate of approximately 10%. Many factors may play a role in the development of MMC such as environmental and genetic factors. In this study, we present our experience with a group of 63 children afflicted with MMC. Methods: This study was a retrospective analysis of 63 patients with MMC admitted to the neurosurgical department of Gabriel Touré Hospital from September 2017 to August 2018. A detailed history was obtained from the family at presentation. The family history and medical information before and during the pregnancy were compiled. Patients underwent complete physical and neurological examinations. Forty-seven (74.60%) patients underwent repair of the MMC and a ventriculoperitoneal shunt was placed in 12 (19%) patients with accompanying hydrocephalus. The risk factors, neurological status, and surgical results have been analyzed. Results: Of 63 children with MMC admitted to our neurosurgical department, 34 (54%) were boys and 29 (46%) were girls. Forty (63.49%) patients were the children of marriages of second cousins or closer. The mean age of the fathers was 34 years (16 - 65), while that of mothers was 26 years (16 - 38). The pregnancy was unplanned in all cases. Fourteen (22.22%) mothers had genitourinary infections, 9 (14.3%) had malaria and 57 (90.47%) mothers used analgesics and antibiotics during the pregnancy. Fifty-nine (93.65%) children were born at term, 58 (92%) were delivered via normal spontaneous vaginal delivery, and 5 (8%) via cesarean section. Lumbosacral lesions were the most frequent in 27 (42.86%) patients. Forty-seven (74.60%) patients underwent r