ARTICLE OPEN Viral dynamics and antibody responses in people with asymptomatic SARS-CoV-2 infection

作     者：Zhiwei Sui Xinhua Dai Qingbin Lu Yulan Zhang Min Huang Shufen Li Tao Peng Jie Xie Yongzhuo Zhang Chunchen Wu Jianbo Xia Lianhua Dong Jiayi Yang Wenfeng Huang Siyuan Liu Ziquan Wang Ke Li Qingfang Yang Xi Zhou Ying Wu Wei Liu Xiang Fang Ke Peng Zhiwei Sui;Xinhua Dai;Qingbin Lu;Yulan Zhang;Min Huang;Shufen Li;Tao Peng;Jie Xie;Yongzhuo Zhang;Chunchen Wu;Jianbo Xia;Lianhua Dong;Jiayi Yang;Wenfeng Huang;Siyuan Liu;Ziquan Wang;Ke Li;Qingfang Yang;Xi Zhou;Ying Wu;Wei Liu;Xiang Fang;Ke Peng

作者机构：Center for Advanced Measurement ScienceNational Institute of MetrologyBeijingChina Department of Laboratorial Science and TechnologySchool of Public HealthPeking UniversityBeijingChina State Key Laboratory of VirologyWuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanHubeiChina Joint Laboratory of Infectious Diseases and HealthWuhan Institute of Virology and Wuhan Jinyintan HospitalWuhanChina Department of Laboratory MedicineHuazhong University of Science and TechnologyTongji HospitalTongji Medical CollegeHUSTWuhanHubeiChina Department of Laboratory MedicineMaternal and Child Health Hospital of Hubei ProvinceTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Shenzhen Mindray Bio-Medical Electronics Co.Ltd.ShenzhenChina University of Chinese Academy of SciencesBeijingChina State Key Laboratory of Virology/Institute of Medical Virology and School of Basic Medical SciencesWuhan UniversityWuhanChina Key Laboratory of Pathogen and BiosecurityBeijing Institute of Microbiology and EpidemiologyBeijingChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第6期

页      面：1788-1794页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Science and Technology Major Project(No.2018ZX10101004001005) the National Key R&D Program of China(2018YFA0507201) the National Natural Science Foundation of China(No.31770188,32070179 and 31900144) Fundamental Research Funds for Central Public Welfare Scientific Research Institutes sponsored by National Institute of Metrology,P.R.China(grant no.31-ZYZJ2001 and grant no.AKYYJ2009) the Advanced Customer Cultivation Project of Wuhan National Biosafety Laboratory Chinese Academy of Sciences(No.2018ACCP-MS01) the Key Technology Development Program of Shenzhen(grant no.JSGG20200225153042494) 

主　　题：asymptomatic admitted immunity 

摘      要：Over 40% of the coronavirus disease 2019(COVID-19)COVID-19 patients were asymptomatically infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and the immune responses of these asymptomatic individuals is a critical factor for developing the strategy to contain the COVID-19 ***,we determined the viral dynamics and antibody responses among 143 asymptomatic individuals identified in a massive screening of more than 5 million people in eight districts of Wuhan in May *** individuals were admitted to the government-designated centralized sites in accordance with *** incidence rate of asymptomatic infection is〜2.92/100,*** individuals had low viral copy numbers(peaked at 315 copies/mL)and short-lived antibody responses with the estimated diminish time of 69 *** antibody responses in individuals with persistent SARS-CoV-2 infection is much longer with the estimated diminish time of 257 *** results imply that the immune responses in the asymptomatic individuals are not potent enough for preventing SARS-CoV-2 re-infection,which has recently been reported in recovered COVID-19 *** casts doubt on the efficacy of formingherd-immunitythrough natural SARS-CoV-2 infection and urges for the development of safe and effective vaccines.