Lipid accumulation and protein modifications of Bruch’s membrane in age-related macular degeneration
作者机构：Department of OphthalmologyPeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Key Laboratory of Ocular Fundus DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China
出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)
年 卷 期：2021年第14卷第5期
页 面：766-773页
核心收录：
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
主 题：Bruch’s membrane lipid accumulation protein modifications therapy
摘 要：Age-related macular degeneration(AMD)is a progressive retinal disease,which is the leading cause of blindness in western *** is an urgency to establish new therapeutic strategies that could prevent or delay the progression of AMD more *** now,the pathogenesis of AMD has remained unclear,limiting the development of the novel ***’s membrane(BM)goes through remarkable changes in AMD,playing a significant role during the disease *** main aim of this review is to present the crucial processes that occur at the level of BM,with special consideration of the lipid accumulation and protein ***,some therapies targeted at these molecules and the construction of BM in tissue engineering of retinal pigment epithelium(RPE)cells transplantation were ***,this review may provide a reference for researchers engaged in pathogenesis or management on AMD.
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