The molecular mechanisms of MLKL-dependent and MLKL-independent necrosis
作者机构：Laboratory of Aging Research and Cancer Drug TargetState Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China Department of Gynecology and ObstetricsDevelopment and Related Disease of Women and Children Key Laboratory of Sichuan ProvinceKey Laboratory of Birth Defects and Related Diseases of Women and ChildrenMinistry of EducationWest China Second Hospitaland State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China
出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)
年 卷 期：2021年第13卷第1期
页 面：3-14页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 071009[理学-细胞生物学]
基 金：This work was supported by the National Major Scientific and Technological Special Project for‘Significant New Drugs Development’(2018ZX09733001) the National Key Research and Development Program of China(2016YFA0201402) and National Natural Science Foundation Regional Irmovation and Development(U19A2003). The authors would like to thank Wen Nie and Min Luo for their assistance with the manuscript preparation.
主 题：MLKL necrosis necroptosis mechanism diseases
摘 要：Necrosis,a type of unwanted and passive cell demise,usually occurs under the excessive external stress and is considered to be unregulated.However,under some special conditions such as caspase inhibition,necrosis is regulable in a well-orchestrated way.The term regulated necrosis has been proposed to describe such programed necrosis.Recently,several forms of necrosis,including necroptosis,pyroptosis,ferroptosis,parthanatos,oxytosis,NETosis,and Na^(+)/K^(+)ATPasimediated necrosis,have been identified,and some crucial regulators governing regulated necrosis have also been discovered.Mixed lineage kinase domain-like pseudokinase(MLKL),a core regulator in necroptosis,acts as an executioner in response to ligands of death receptor family.Its activation requires the receptor-interacting protein kinases,RIP1 and RIP3.However,MLKL is only involved in necroptosis,i.e.MLKL is dispensable for necrosis.Therefore,this review is aimed at summarizing the molecular mechanisms of MLKLdependent and MLKL-independent necrosis.
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