Calcium-Sensing Receptor of Immune Cells and Diseases
作者机构：Department of CardiologyThe First Affi liated Hospital of Harbin Medical UniversityHarbin150001 HeilongjiangChina
出 版 物：《Cardiovascular Innovations and Applications》 (心血管创新与应用（英文）)
年 卷 期：2021年第5卷第2期
页 面：257-266页
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
基 金：supported by the National Natural Science Foundation of China for Xinhua Yin and Wenxiu Liu(81370319 and 81700318) the China Postdoctoral Science Foundation for Wenxiu Liu(2018M631957) the Hei Long Jiang Postdoctoral Fund for Wenxiu Liu(LBH-Z17145) Doctor Funds of the First Affi liated Hospital of Harbin Medical University for Wenxiu Liu(201613007) the Innovation and Entrepreneurship Training Program for College Students of Harbin Medical University for Wenxiu Liu(201910226157)
主 题：Calcium-sensing receptor neutrophil monocyte/macrophage T lymphocyte B lymphocyte
摘 要：Calcium-sensing receptor(CaSR),which was initially found in the parathyroid gland,is ubiquitously expressed and exerts specifi c functions in multiple cells,including immune *** is functionally expressed on neutrophils,monocytes/macrophages,and T lymphocytes,but not B lymphocytes,and regulates cell functions,such as cytokine secretion,chemotaxis,phenotype switching,and ligand *** these immune cells,CaSR is involved in the development of many diseases,such as sepsis,cryopyrin-associated periodic syndromes,rheumatism,myocardial infarction,diabetes,and peripheral artery *** its discovery,it has been controversial whether CaSR is expressed and plays a role in immune *** article reviews current knowledge of the role of CaSR in immune cells.
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