Effects of Zao Huang Mixture (藻黄合剂) on the Expressions of TGF-β1 and Col IV in Human Glomerular Mesangial Cells Cultured in High Glucose Environment

作     者：鞠建伟 牟授菡 尹燕志 吕丛奎 孙晓燕 邓磊修 

作者机构：Yantai Economy and Technology Development Zone Hospital Shandong Simcere-Medgenn Bio- pharmaceutical Company 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2011年第31卷第2期

页      面：127-129页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Zao Huang Mixture (藻黄合剂JZHM) transforming growth factor-ill collagen IV human glomerular mesangial cells high glucose environment 

摘      要：Objective: To investigate the effect of Zao Huang Mixture (藻黄合剂ZHM) on expressions of growth factor-β1 (TGF-β1) and collagen IV (Col IV) in human glomerular mesangial cells (GMC) cultured in high-glucose environment. Methods: After primary culture of GMC, in vitro culture was carried out in normal group, high glucose group and high glucose medium with ZHM of different concentrations, and the expressions of TGF-β1 and Col IV in the GMC group and in ZHM group were detected at 24 and 48 h respectively. Results: Compared with the normal group, expressions of TGF-β1 and Col IV significantly increased at 24 h, 48 h in the high glucose group (all P0.01); Compared with the high glucose group, the expressions of TGF-β1 and Col IV in all the ZHM groups significantly decreased at 24 h, 48 h (P0.05 or P0.01). Conclusion: ZHM may modulate the process of diabetic nephropathy by changing the expression of TGF-β1 and Col IV in glomerular mesangial cells.