Schizophrenia:a classic battle ground of nature versus nurture debate

作     者：David St Clair Bing Lang David St Clair;郎兵

作者机构：Department of PsychiatryThe Second Xiangya HospitalCentral South UniversityNational Clinical Research Center for Mental DisordersChangsha 410011China Institute of Medical SciencesUniversity of AberdeenAberdeen AB252ZDUK Bio-X Life Science Research CenterShanghai Jiao Tong UniversityShanghai 200030China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2021年第66卷第10期

页      面：1037-1046,M0004页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by the Key Research and Development Program from Hunan Province(2018DK2011) the National Natural Science Foundation of China(82071507) 

主　　题：Schizophrenia Nature Nurture Omnigenic 

摘      要：Much has been learned about the etiology and pathogenesis of schizophrenia since the term was first used by Eugene Bleuler over a century ago to describe one of the most important forms of major mental illness to affect *** nature and nurture feature prominently in our understanding of the genesis of the overall risk of developing *** now have a firm grasp of the broad structure of the genetic architecture and several key environmental risk factors have been identified and ***,much of the heritability of schizophrenia remains unexplained and the reported environmental risk factors do not explain all the variances not attributable to genetic risk *** biggest problem at present is that our understanding of the causal mechanisms involved is still in its *** this review,we describe the extent and limits of our knowledge of the specific genetic/constitutional and non-genetic/environmental factors that contribute to the overall risk of *** suggest novel methods may be required to understand the almost certainly immensely complex multi-level causal mechanisms that contribute to the generation of the schizophrenia phenotype.