Hydrothermal synthesis method of 5-(4'-methylbiphenyl-2-yl)-1H-tetrazole

作     者：Wen-Xiang Wang Hong-Ling Cai Ren-Gen Xiong 

作者机构：Ordered Matter Science Research Center Southeast University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2013年第24卷第9期

页      面：783-785页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundations of China(Nos.21101026 20931002 20921004 90922005 and 91022003) 

主　　题：Tetrazole Hydrothermal synthesis Propane-1 2-diol Sartan 

摘      要：A clean and saIe synthesis method of 5-（4＇-methylbiphenyl-2-yl）-1H-tetrazole was round： under hydrothermal conditions, 1.2 equiv, of 4＇-methylbiphenyl-2-carbonitrile react with 1 equiv, of sodium azide in a mixed solvent of propane-1,2-diol/H2O, with 1.5 equiv, of ammonium chloride and 0.2 equiv. of ammonium fluoride as catalyst. After simple post-processing, the yield can be improved to 95%, and the purity of the product is 99% without further recrystaUization.