New strategy for sepsis: Targeting a key role of platelet-neutrophil interaction

作     者：Xu Wang Weiting Qin Bingwei Sun 

作者机构：Department of Burn and Plastic SurgeryAffiliated HospitalJiangsu UniversityZhenjiangJiangsuChina 

出 版 物：《Burns & Trauma》 (烧伤与创伤（英文）)

年 卷 期：2014年第2卷第3期

页      面：114-120页

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 1011[医学-护理学（可授医学、理学学位）] 100214[医学-肿瘤学] 0836[工学-生物工程] 10[医学] 

基　　金：National Natural Science Foundation of China  No. 30772256  81071546 and No. 81272148  and Jiangsu Provincial Natural Science Founda-tion  No. BK2012703 

主　　题：Sepsis neutrophil platelet interaction 

摘      要：Neutrophil and platelet are essential arms of the innate immune response. In sepsis, platelet abnormal activation as well as neu-trophil paralysis are well recognized. For platelet, it is characterized by the contribution to disseminated intravascular coagulation (DIC) and the enhanced inflammation response. In terms of neutrophil, its dysfunction is manifested by the impaired recruitment and migration to the infectious foci, abnormal sequestration in the remote organs, and the delayed clearance. More recently, it has been apparent that together platelet-neutrophil interaction can induce a faster and harder response during sepsis. This article focuses on the activation of platelet, dysfunction of neutrophil, and the interaction between them during sepsis and profiles some of the molecular mechanisms and outcomes in these cellular dialogues, providing a novel strategy for treatment of sepsis.