A disease-relevant mutation of SPOP highlights functional significance of ATM-mediated DNA damage response

作     者：Mingming Xiao Joshua S.Fried Jinlu Ma Yang Su Rebecca J.Boohaker Qinghua Zeng Yaqi Mo Fanbiao Meng Rong Xiang Bo Xu Mingming Xiao;Joshua S.Fried;Jinlu Ma;Yang Su;Rebecca J.Boohaker;Qinghua Zeng;Yaqi Mo;Fanbiao Meng;Rong Xiang;Bo Xu

作者机构：Department of Biochemistry and Molecular BiologyKey Laboratory of Breast Cancer Prevention and TherapyMinistry of EducationTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300060China Department of OncologySouthern Research InstituteBirminghamAL 35205USA Cell Biology ProgramUniversity of Alabama at BirminghamBirminghamAL 35205USA Department of Radiation OncologyFirst Afliated HospitalXian Jiaotong UniversityXi'anChina Department of Biochemistry and Molecular BiologyNankai University School of MedicineTianjinChina Center for Itelligent OncologyChongqing University Cancer HospitalChongqing University School of MedicineChongqing 400030China 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第2期

页      面：235-237页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：This work was supported by grants from the National Natural Science Foundation of China[81672743,81974464 and 81972861] Bejing-Tanjin-Hebei Basic Research Cooperation Project[19JCZDJC64500(Z)] the Alabama Innovation Fund,from the Ministry of Science and Technology[2016YFC0904601] Shenzhen Basic Research Project(JCYJ20160331114230843) Tianjin Medical University Cancer Institute and Hospital Innovation Fund. 

主　　题：damage DDR ATM 

摘      要：Dear Editor,Accumulating evidence supports that,as a critical genome guardian mechanism,the DNA damage response(DDR)is a barrier to early tumorigenesis.As a crucial DDR pathway,Ataxia Telangiectasia Mutated(ATM)-mediated phosphorylation of downstream targets is essential for activation of cell cycle checkpoints,DNA repair,and programed cell death in the presence of DNA damage.Despite extensive biochemical and cellular studies on ATM phosphorylation,these phosphorylation sites are rarely mutated in cancers,challenging the pathophysio-logical relevance of ATM-mediated phosphorylation in the disease setting.