Silica Supported Perchloric Acid： A Convenient and Environmentally Friendly Catalyst for the One-pot Multicomponent Synthesis of ,β-Acetamido Ketones

作     者：Nasr-Esfahani, Masoud Montazerozohori, Morteza Gholampour, Tahere 

作者机构：Department of Chemistry Yasouj University Yasouj 75918-74831 Iran 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2011年第29卷第1期

页      面：123-130页

核心收录：

学科分类：081705[工学-工业催化] 08[工学] 0817[工学-化学工程与技术] 

主　　题：silica supported perchloric acid β-acetamido ketone Dakin-West reaction supported catalyst multicomponent reaction 

摘      要：A modified Dakin-West one-pot, four-component condensation of an aryl aldehyde, aryl ketone, acetyl chloride and acetonitrile in the presence of silica supported perchloric acid as an active, inexpensive, recoverable and recyclable catalyst is reported for the synthesis of β-acetamido ketones under mechanical stirring and ultrasonic irradiation conditions. This system has advantages of short reaction times, good to excellent yields and the ability to carry out the large scale reactions. The use of ultrasound increases the rate of reactions compared with reactions at reflux conditions.