Binary organic nanoparticles with enhanced reactive oxygen species generation capability for photodynamic therapy

作     者：Xiaofu Weng Zhouzhou Bao Xunbin Wei Xiaofu Weng;Zhouzhou Bao;Xunbin Wei

作者机构：School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030P.R.China Department of Obstetrics and Gynecology Ren Ji HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghai 200127P.R.China Shanghai Key Laboratory of Gynecologic Oncology Ren Ji HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghai 200127P.R.China 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2021年第4卷第3期

页      面：52-59页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：This work was supported by the National Nature Science Foundation of China(Grant Nos.61425006,61227017 and 81573382) the National Key Research and Development Program of China(2019YFC1604604) Program of Shanghai Technology Research Leader(Grant No.17XD1402200) Shanghai Jiao Tong University(ZH2018QNA43) Open Project Program of Wuhan National Laboratory for Optoelectronics(2019WNLOKF019) 

主　　题：Aggregation-induced emission photodynamic therapy organic nanoparticles 

摘      要：Photodynamic therapy(PDT)takes advantage of photosensitizers(PSs)to generate reactive oxygen species(ROS)for cell killing when excited by *** has been widely used in clinic for therapy of multiple ***,all the FDA-approved PSs,including porphyrin,are all small organic molecules,suffering from aggregation-caused quenching(ACQ)issues in biological environment and lacking tumor targeting ***(NPs)with size between 20 nm and 200 nm possess tumor targeting capability due to the enhanced permeability and retention(EPR)*** is urgent to develop a new strategy to form clinical-approved-PSs-based NPs with improved ROS generation *** this study,we report a strategy to overwhelm the ACQ of porphyrin by doping it with a type of aggregation-induced emission(AIE)luminogen to produce a binary NPs with high biocompatibility,and enhanced fluorescence and ROS generation *** NPs can be readily synthesized by mixing a porphyrin derivative,Ce6 with a typical AIE luminogen,***,our experimental results have demonstrated the feasibility and effectiveness of this strategy,endowing it a great potential in clinical applications.