Alum colloid encapsulated insideβ-glucan particles enhance humoral and CTL immune responses of MUC1 vaccine

作     者：Yonghui Liu Mingjing Li Haomiao Zhu Zhe Jing Xiaona Yin Kun Wang Zhangyong Hong Wei Zhao Yonghui Liu;Mingjing Li;Haomiao Zhu;Zhe Jing;Xiaona Yin;Kun Wang;Zhangyong Hong;Wei Zhao

作者机构：State Key Laboratory of Medicinal Chemical BiologyCollege of Pharmacy and KLMDASR of TianjinNankai UniversityTianjin 300353China State Key Laboratory of Medicinal Chemical Biology&Tianjin Key Laboratory of Protein SciencesCollege of Life SciencesNankai UniversityTianjin 300071China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第6期

页      面：1963-1966页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.22077068) the National Key R&D Program of China(No.2018YFA0507204) the NCC Fund(No.NCC2020FH12) the Natural Science Foundation of Tianjin(No.19JCQNJC05300) the Fundamental Research Funds for the Central Universities 

主　　题：MUC 1 antigen Glycopeptide GP-Al Adjuvant Antitumor vaccine 

摘      要：We have developed a MUC1 antigen-based antitumor vaccine loaded on alum colloid encapsulated insideβ-glucan particles(GP-Al).The constructed vaccine induced strong MUC1 antigen specific Ig G antibody titers and enhanced CD^(8+)T cells cytotoxic effect to kill tumor *** results indicated that GP-Al can be served as an efficient delivery system and adjuvant for the development of cancer vaccines especially small molecule antigens based cancer vaccines.