Skeletal muscle stiffness as measured by magnetic resonance elastography after chronic spinal cord injury:a cross-sectional pilot study

作     者：Mina P.Ghatas M.Rehan Khan Ashraf S.Gorgey Mina P.Ghatas;M.Rehan Khan;Ashraf S.Gorgey

作者机构：Department of Spinal Cord Injury and DisordersHunter Holmes McGuire VA Medical CenterRichmondVAUSA Department of RadiologyHunter Holmes McGuire VA Medical CenterRichmondVAUSA Department of Physical Medicine and RehabilitationVirginia Commonwealth UniversityRichmondVAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第12期

页      面：2486-2493页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100104[医学-病理学与病理生理学] 10[医学] 

主　　题：chronic spinal cord injury isometric and isokinetic torques magnetic resonance elastography muscle size rehabilitation shear modulus spasticity stiffness 

摘      要：Skeletal muscle stiffness is altered after spinal cord injury(SCI).Assessing muscle stiffness is essential for rehabilitation and pharmaceutical interventions design after *** study used magnetic resonance elastography to assess the changes in stiffness after chronic SCI compared to matched able-bodied controls and determine its association with muscle size,spasticity,and peak torque in persons with *** studies examined the association between muscle stiffness and spasticity,however,we are unaware of other studies that examined the effects of muscle composition on stiffness after *** participants(one female)with chronic SCI and eight(one female)matched able-bodied controls participated in this cross-sectional *** resonance elastography was utilized to monitor stiffness derived from shear waves *** Ashworth scale was used to evaluate spasticity scores in a blinded *** isometric and isokinetic torques were measured using a biodex *** values were non-significantly lower(12.5%;P=0.3)in the SCI group compared to able-bodied ***,stiffness was positively related to vastus lateralis whole muscle cross-sectional area(CSA)(r2=0.64,P0.005)and vastus lateralis absolute muscle CSA after accounting for intramuscular fat(r2=0.78,P0.0007).Stiffness was also positively correlated to both isometric(r2=0.55-0.57,P0.05)and isokinetic peak(r2=0.46-0.48,P0.05)*** results suggest that larger clinical trial is warranted to confirm the preliminary findings that muscle stiffness is altered after SCI compared to healthy *** appeared to be influenced by infiltration of intramuscular fat and modestly by the spasticity of the paralyzed *** preliminary data indicated that the relationship between muscle stiffness and peak torque is not altered with changing the frequency of pulses or angular *** study procedures were approved by the Institutional Review Board at the