D-A-D structured selenadiazolesbenzothiadiazole-based near-infrared dye for enhanced photoacoustic imaging and photothermal cancer therapy

作     者：Zijin Cheng Tian Zhang Weili Wang Qing Shen Ying Hong Jinjun Shao Xiaoji Xie Zhenghao Fei Xiaochen Dong Zijin Cheng;Tian Zhang;Weili Wang;Qing Shen;Ying Hong;Jinjun Shao;Xiaoji Xie;Zhenghao Fei;Xiaochen Dong

作者机构：Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(1AM)Nanjing Tech UniversityNanjing 210009China Applied Chemistry&Environmental EngineeringYancheng Teachers UniversityYancheng 224051China School of Chemistry and Materials ScienceNanjing University of Information Science&TechnologyNanjing 210044China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第4期

页      面：1580-1585页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Natural Science Foundation of Jiangsu Province(No.BK20200092) National Natural Science Foundation of China(No.52072172) Six Talent Peak Innovation Team in Jiangsu Province(No.TD-SWYY-009) 

主　　题：Photothermal Near-infrared dye Cancer therapy Donor-acceptor Selenadiazolesbenzothiadiazole 

摘      要：Near-infrared(NIR)small molecular organic dyes as photothermal agents for cancer photothermal therapy(PTT)have attracted considerable research ***,two donor-acceptor-donor(D-A-D)structured NIR dyes,BBTT and SeBTT,are rationally designed,where the only difference is one heteroatom within the acceptor unit varying from sulfur to selenium(Se).More importantly,SeBTT NPs exhibit stronger NIR absorbance and higher photothermal conversion efficiency(PTCE≈65.3%).In vivo experiments illustrate that SeBTT NPs can be utilized as a high contrast photoacoustic imaging(PAI)agent,and succeed in tumor suppression without noticeable damage to main organs under NIR *** study presents an effective molecular heteroatom surgery strategy to regulate the photothermal properties of NIR small molecules for enhanced PAI and PTT.