(+)-/(-)-Angelignanine,a pair of neolignan enantiomers with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head

作     者：Youzhe Chen Qinglan Guo Chengbo Xu Chenggen Zhu Jianjun Zhang Jiangong Shi Youzhe Chen;Qinglan Guo;Chengbo Xu;Chenggen Zhu;Jianjun Zhang;Jiangong Shi

作者机构：State Key Laboratory of Bioactive Substance and Function of Natural MedicinesInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第5期

页      面：1657-1659页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

基　　金：Financial support from the National Natural Sciences Foundation of China(No.81630094) CAMS Innovation Fund for Medical Science(No.2017-I2M-3-010) The Drug Innovation Major Project(No.2018ZX09711001-001)is acknowledged 

主　　题：Umbelliferae Angelica sinensis Neolignan 2,7/-Cyclo-8,9/-neolignan (+)-/(-)-Angelignanine 

摘      要：A pair of neolig nan enan tiomers with an unprecedented carb on skelet on,(+)-/(-)-angeligna nine[(+)-/(-)-1].was isolated as minor components of an aqueous extract of the Angelica sinensis root heads(guitou).Their structures were determined by spectroscopic data analysis and the absolute configurations were assigned by the circular dichroism(CD)exciton chirality method as well as electronic CD quantum *** enantiomers represent the first 2,7/-cyclo-8,9z-neolignans,of which biosynthetic pathways originating from precursors ferulic acid and coniferyl alcohol is *** an in vivo test,both the enantiomers showed significant hypnotic effects at a dose of 10 mg/kg(i.g.).